Highway 53 was closed for nearly two hours Saturday night, after a head on collision killed 4 people, and critically injured 1 person.
The accident happened at the intersection of Canal Road and Highway 53.
According to Harrison County Coroner Gary Hargrove, 38 year old Deborah Stewart of Gulfport was driving westbound , when her car crossed over and hit a car carrying William and Samantha Downs, and set both cars on fire.
The Downs were pronounced dead at the scene, from blunt force trauma injuries.
24-year-old Chris Dafoe, who was riding with the Downs, was taken to Garden Park hospital.
He later died at the hospital from blunt force injuries to the head and neck.
A fifth person, 25 year old Patricia Williams of Gulfport, who was riding with Stewart, was airlifted to the USA Medical Center.
She is in critical condition after undergoing surgery.