Drew Brees threw two touchdown passes in the first quarter and led New Orleans to a 23-17 win at Indianapolis on Saturday night.
After missing more than two weeks of practice and the Saints' first two preseason games with a strained left side muscle, Brees showed no sign of rustiness. He went 9 of 15 for 128 yards with no interceptions for New Orleans (3-0).
Six-time Pro Bowl receiver Reggie Wayne suited up for the Colts (0-3) for the first time since tearing his right ACL last October, but Indy's offense struggled.
Andrew Luck played into the third quarter and finished 10 of 18 for 103 yards with one TD and one interception. Wayne caught two passes, both of which were wiped out by penalties.
Brees' 13-yard TD pass to Marques Colston made it 14-7 and the Saints never trailed again.
(Copyright 2014 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.)